Cannabis, Anxiety and the Brain: Inside the Fear Circuit

Send us Fan Mail Why does the same cannabis leave one person blissful and another certain the sirens are coming? In this Heliox deep dive, we follow fear into the brain of a mouse, past a lens thinner than a needle and into the central amygdala. Researchers at Northwestern University's Feinberg School of Medicine, led by Dr. Sachin Patel, found that cannabinoids weaken the GABA "brake" on fear-driving somatostatin neurons. When stress hits the gas at the same moment, anxiety can spiral. When those neurons were silenced, the mice calmed down. We explore what this means for set and setting, rising ER visits for panic, the alcohol-versus-cannabis culture war, and the future of anxiety treatment. We also ask: which fears should we keep. Reference: Why Too Much Cannabis Can Flip an Anxiety Switch in the Brain 📖 Read: https://helioxpodcast.substack.com 🎥 YouTube : https://www.youtube.com/channel/UCd5BbCEeC3Z6dp-nNjWRbBw 🎙️ Available for Broadcast: https://exchange.prx.org/group_accounts/253118-heliox_where_evidence_meets_empathy This is Heliox: Where Evidence Meets Empathy Independent, moderated, timely, deep, gentle, clinical, global, and community conversations about things that matter. Breathe Easy, we go deep and lightly surface the big ideas. Support the show Disclosure: This podcast uses AI-generated synthetic voices for a material portion of the audio content, in line with Apple Podcasts guidelines. We make rigorous science accessible, accurate, and unforgettable. Produced by Michelle Bruecker and Scott Bleackley, it features reviews of emerging research and ideas from leading thinkers, curated under our creative direction with AI assistance for voice, imagery, and composition. Systemic voices and illustrative images of people are representative tools, not depictions of specific individuals. We dive deep into peer-reviewed research, pre-prints, and major scientific works—then bring them to life through the stories of the researchers themselves. Complex ideas become clear. Obscure discoveries become conversation starters. And you walk away understanding not just what scientists discovered, but why it matters and how they got there. Independent, moderated, timely, deep, gentle, clinical, global, and community conversations about things that matter. Breathe Easy, we go deep and lightly surface the big ideas. Spoken word, short and sweet, with rhythm and a catchy beat. http://tinyurl.com/stonefolksongs