Is Real-World Data Better Than Clinical Trials? | Dr. Uli Chettipally on Beyond the Scalpel with Dr. Alrashid

Send us Fan Mail Is real-world data better than clinical trials? Could AI change how we evaluate medical evidence and choose treatments? In this episode of Beyond the Scalpel, Dr. Mamun Alrashid sits down with Dr. Uli Chettipally, an emergency physician, researcher, and healthcare entrepreneur, to explore how patient data can inform clinical decisions and why physician judgment remains essential. Dr. Chettipally shares his experience developing clinical decision support at Kaiser Permanente, discusses the potential of real-world evidence, and explains why he believes physicians should help lead healthcare innovation. The conversation also explores the personal story behind Sirica Therapeutics, its early-stage work combining virtual reality, gaming, and whole-body movement for autistic individuals, and the research planned to evaluate that approach. Through InnovatorMD, Dr. Chettipally also helps clinicians develop the skills and connections needed to bring their ideas into practice. EPISODE TIMESTAMPS 00:00 Meet Dr. Uli Chettipally 01:04 From emergency medicine to population health 02:36 Using patient data to predict risk and guide care 05:34 Balancing algorithms with clinical judgment 06:50 Testing decision support and preserving physician autonomy 09:51 The personal journey behind Sirica Therapeutics 14:00 Measuring outcomes and planning autism research 15:12 InnovatorMD and the role of physician innovators 18:40 The biggest mindset challenge for physician founders 20:29 Where AI could change patient outcomes 23:58 Real-world evidence vs. clinical trials 26:45 Future projects and improving communication access 29:24 Rapid-fire questions 30:46 Closing thoughts Can real-world evidence change how we define the gold standard in medical research? Share your perspective in the comments. If you enjoyed this episode, be sure to Like, Subscribe, and Share for more conversations with world-renowned physicians, innovators, and healthcare leaders on Beyond the Scalpel with Dr. Mamun AlRashid. Disclaimer: The views and opinions expressed by our guests are their own and do not necessarily reflect the views of Beyond the Scalpel, Dr. Mamun AlRashid, or its affiliated organizations. This podcast is intended for educational and informational purposes only and should not be considered medical advice. Follow us: Official Website: https://palmbeachregenerativeorthopedics.com/ Facebook: https://www.facebook.com/BeyondTheScalpel Instagram: https://www.instagram.com/beyond.the_scalpel/ YouTube: https://www.youtube.com/@Beyond.The_Scalpel LinkedIn: https://www.linkedin.com/company/beyond-the-scalpel-with-dr-alrashid/ X: https://x.com/BeyondTheScalpe Threads: https://www.threads.com/@beyond.the_scalpel TikTok: https://www.tiktok.com/@beyond.the_scalpel Pinterest: https://www.pinterest.com/BeyondTheScalpel1/ Spotify: https://open.spotify.com/show/033Aj8vvEr7Pz9Se02Yo1F?si=7ac5299e36ce4f5f Beyond the Scalpel is produced by Palm Beach Media Productions.