E225: Pierre Montay-Gruel - Radiobiology and the FLASH Revolution

Trigger Warning: this episode discusses cancer and cancer treatment. Episode 225: Part of the Education and Workforce Development series (Part 77) Description: In this fascinating episode, Naman Julka-Anderson and Jo McNamara sit down with Dr. Pierre Montay-Gruel. Pierre graduated from the École Normale Supérieure de Cachan and Université Paris-Sud 11 with training in oncology and radiobiology. He obtained his PhD in 2018 through a joint programme between the University of Lausanne and Université Paris-Sud under Prof. Marie-Catherine Vozenin, where he was among the first researchers investigating FLASH radiotherapy for glioblastoma and normal brain preservation. Following a postdoctoral fellowship at the University of California, Irvine, he joined Iridium Netwerk in Antwerp as Radiobiology Group Leader and is a Visiting Professor at the University of Antwerp. His research focuses on FLASH radiotherapy and its clinical translation. Pierre is actively involved in ESTRO, serving on the Scientific Council, FLASH Focus Group, Early Career Committee and Equity, Diversity and Inclusion Working Group, and coordinating the ESTRO Mentorship Programme. This episode is a deep dive into the fundamentals of radiobiology, the Rs of radiobiology behind fractionation, why patients respond differently to radiotherapy, the science and promise of FLASH radiotherapy, and why Pierre believes we should never forget ourselves in the process. CPD Reflection Points: Applying the Rs of radiobiology: Pierre explained how repair, reoxygenation, redistribution and immune reactivation underpin fractionated radiotherapy. How confidently could you explain to a patient why their treatment is delivered in fractions, and how could you use radiobiology to strengthen the way you discuss side effects, treatment gaps or lifestyle factors such as exercise? Individual radiosensitivity: Pierre described how genetic differences can make some patients far more sensitive to radiation, and how biomarkers may one day allow screening before treatment. When a patient develops unexpectedly severe side effects, how do you currently recognise, document and escalate this, and how might personalised radiosensitivity testing change your role in the future? From bench to bedside: Pierre discussed the long journey from preclinical models to clinical use of FLASH radiotherapy, and his hope for a truly interdisciplinary community that involves patients. How do you stay informed about emerging techniques such as FLASH, and what could you do to strengthen links between your clinical team, researchers and patients? Complete this form for your accredited digital badge: Digital Badge Form . Links from the Episode: Pierre's first paper: Irradiation in a flash Éric Deutsch – Gustave Roussy Institut Curie Vincent Favaudon – Institut Curie Marie-Catherine Vozenin research group – University of Geneva ESTRO Early Career Committee ESTRO Mentoring Programme <a href="https://christie.nhs.uk/your-treatment-and-care/treatments/radiotherapy/types-of-radiotherapy-we-offer/bladder-carbogen-