Daily Briefing for November 8, 2026

Stents or bypass for stable heart disease add no survival at 11 years The voices on this episode are generated, and so is the script, from the day's post at Physician in the Loop. Every fact in the post links to its source. Read the post and its sources Get the free email briefing Routine angiography and revascularization for stable coronary disease with moderate or severe ischemia did not extend survival over 11 years compared with medicines alone, according to ISCHEMIA follow-up data JAMA published Saturday. The same day at the American Heart Association's Scientific Sessions in Chicago, full results showed that pelacarsen, which cut lipoprotein(a) by 78%, and the interleukin-6 antibody ziltivekimab, which lowered CRP, did not reduce major cardiovascular events. A randomized trial of AI-screened ECGs found a statistically fragile gain in atrial fibrillation detection, and a Stanford study using a language model found lipid therapy was left unchanged at 89% of visits where LDL was above goal. Weill Cornell Medicine disclosed that patient imaging details were entered into AI tools without authorization for a radiology research study in June. In this episode Routine stents or bypass for stable coronary disease add no survival over medicines alone at 11 years in 5,179-patient ISCHEMIA follow-up Two heart drugs fail in full results: pelacarsen cut lipoprotein(a) 78% and ziltivekimab cut CRP, but neither prevented heart attacks or strokes An AI-flagged ECG raised detection of atrial fibrillation or its precursors by a fragile margin in a 14,665-adult randomized trial A language model reading clinic notes found lipid therapy was not intensified at 89% of visits where LDL sat above goal Starting statin plus ezetimibe up front did not cut cardiovascular events at 3 years versus a statin alone in a 3,048-patient trial Weill Cornell says patient imaging details were fed into AI tools without authorization for a radiology research study