Thermodynamics Made Simple for the MCAT: Gibbs Free Energy, Enthalpy, Entropy, and Spontaneous Reactions

Thermodynamics is one of the most important chemistry concepts tested on the MCAT, particularly when evaluating chemical reactions, metabolic pathways, and energy transfer. This episode explains Gibbs free energy, enthalpy, entropy, and the relationship between spontaneity and equilibrium using practical examples and straightforward calculations. You’ll also learn how ATP hydrolysis drives unfavorable biological reactions, why temperature can change reaction spontaneity, and how to avoid common MCAT exam traps.