Latest HPV Cervical Guidelines: ACOG and HPV 56/59/66

Yes, we have covered cervical cancer screening many, many times on this show. It is truly a testament to science and research just how far we have come from using slide-based cytology for cervical cancer screening. Primary high-risk HPV, as a screening modality, has been favored for many years and is now officially part of the age-based, ACOG cervical cancer screening guideline (July 2026). We will summarize that update in this episode. Plus, we will also review about what to do when the hrHPV expanded genotype panel returns positive for 56/59/66. Modern cervical screening reports frequently refer to HPV 56, 59, and 66, typically grouping them together into a single pooled result (often labeled as a trio "HPV 56/59/66"). This is due to the widespread adoption of extended HPV genotyping technology. WE, what do we do with that? Listen in for details. 1. ACOG Committee Statement No. 28: Screening for Cervical Cancer; July 2026 2. Massad LS, Clarke MA, Perkins RB, Garcia F, Chelmow D, Cheung LC, Darragh TM, Egemen D, Lorey TS, Nayar R, Newman M, Risley C, Smith RA, Wentzensen N; Enduring Consensus Cervical Cancer Screening and Management Guidelines Committee. Applying Results of Extended Genotyping to Management of Positive Cervicovaginal Human Papillomavirus Test Results: Enduring Guidelines. J Low Genit Tract Dis. 2025 Apr 1;29(2):134-143. PMC11939109.